Blood Markers in Long Covid May Lead to Future Clinical Trials

A recent UK study has revealed that individuals with Long Covid may have ongoing inflammation in their bloodstream, shedding light on the nature of the condition and potential treatment approaches. Researchers have identified specific proteins that increase the risk of symptoms such as fatigue, especially in those who were hospitalised due to severe Covid infection.

Long Covid, defined as symptoms persisting for at least 12 weeks following a Covid infection, is believed to have impacted millions globally. Common symptoms include severe fatigue, shortness of breath, and cognitive issues like memory problems, often referred to as "brain fog." Other symptoms may include insomnia, loss of smell, and anxiety. Interestingly, the likelihood of developing long-term symptoms doesn't necessarily correlate with the severity of the initial infection.

Imperial College London conducted the largest study on Long Covid in the UK, tracking 659 hospital patients with severe cases of the virus. Six months post-infection, 426 participants reported ongoing symptoms, while 233 had fully recovered. Those still experiencing symptoms showed active and continuous patterns of inflammatory proteins in their blood, indicating an unusual response long after the initial infection.

The UK Department of Health and Social Care has supported the study as part of a broader initiative, investing over £50 million in research to better understand and find new treatments for Long Covid, recognising its significant impact on individuals' physical and mental health.

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