A revolutionary new treatment has shown remarkable results in a woman with a brain tumour, with nearly complete regression in less than a week. The 57-year-old experienced dramatic improvement after undergoing CAR-T therapy, a treatment that enhances the body's immune response.
She was one of three glioblastoma patients in a study from March to July 2023, all of whom saw significant tumour reduction. Dr. Elizabeth Gerstner from Massachusetts General Hospital noted the dramatic and rapid response in these patients, highlighting the progress but also the need for further research.
Glioblastomas are highly aggressive brain tumours affecting around 3,200 people annually in the UK. Traditional treatments include surgery, radiotherapy, and chemotherapy. This new study, published in the New England Journal of Medicine, evaluated CAR-T therapy's effectiveness in treating this condition. Originally used for certain blood cancers, CAR-T therapy trains the immune system to target cancer cells. The woman experienced "near-complete tumour regression" in just five days. The other patients also saw reductions, with a 72-year-old man's tumour shrinking by over 18% in two days and by 60.7% by day 69, sustaining for over six months.
Dr. Marcela Maus of Massachusetts General Hospital called the results promising, though emphasised that curing the disease remains the ultimate goal.